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Posts Tagged ‘genetic factor’

Is Vitamin B12 Deficiency a Genetic Mutation?

Tuesday, September 17th, 2013



About half the population has a gene mutation making them prone to genetic vitamin B12 deficiency, according to researchers, which would explain the growing epidemic of pernicious anemia from untreated vitamin B12 deficiency. About 40 percent of people between the ages of 26 and 83 have dangerously low levels of vitamin B12, and many don’t even realize it until the debilitating symptoms begin to set in. Here are the facts on genetic vitamin B12 deficiency.

Is Vitamin B12 Deficiency a Genetic Mutation?

The MTHFR gene and B12 Deficiency

Everybody has two MTHFR genes, one from each parent. These genes are necessary for efficiently converting vitamin B12 to a usable form, and in effect also maintaining healthy homocysteine levels.

If you have defective MTHFR genes, then you’re not able to convert cobalamin to usable vitamin B12 as effectively as somebody without the gene defect.

However, nearly 50% of all people have a defected MTHFR gene from one parent, and 10% have mutated MTHFR genes from both parents, making them more likely to suffer genetic vitamin B12 deficiency, and also elevated levels of homocysteine, which has been linked to hardening of the arteries and increased risk for heart attack.

Causes for Vitamin B12 Deficiency

Vitamin B12 absorption is a complicated process, and there are many things that can go wrong. Certain health conditions, medications, invasive surgeries, dietary restrictions, and yes- genetics- can impede your ability to digest vitamin B12 properly from food sources and vitamin supplements.

Common causes of vitamin B12 deficiency include:

  • Vegan and vegetarian dieting
  • Family history for autoimmune disorders, such as lupus and fibromyalgia
  • Family history for pernicious anemia
  • MTHFR gene mutations
  • Gastrointestinal infections or illnesses, such as leaky gut, Crohn’s, celiac, and Small Intestine Bacterial Overgrowth (SIBO)
  • Bariatric surgeries or ilium removal for Crohn’s treatment
  • Medications such as metformin for diabetes and PPIs for GERD
  • Old age
  • Alcoholism

Find out if you have genetic B12 Deficiency

There are several ways of finding out if you have vitamin B12 deficiency, including plasma vitamin B12 level screening, complete blood count (CBC) and homocysteine blood screening for Hyperhomocysteinemia.

As for testing for the MTHFR gene mutation, there are no official guidelines as to who should be tested. So unless you request a test for genetic vitamin B12 deficiency from a doctor who is able to comply, then your best bet is to stay on top of vitamin B12 and homocysteine levels, and supplement daily with vitamin B12, folate and vitamin B6.

Treating vitamin B12 Deficiency

If you’re tested with genetic vitamin B12 deficiency caused by a gene mutation, or any form of vitamin B12 deficiency that doesn’t stem from diet, then it’s absolutely essential to supplement with vitamin B12 in order to prevent vitamin B12 deficiency and other severe malnutrition. Diet alone will not provide you the amount of vitamin B12 needed in order to prevent pernicious anemia.

Please tell us…

Would you consider getting tested for genetic vitamin B12 deficiency? Do one or both parents also have vitamin B12 deficiency or pernicious anemia?

Do you have any questions or suggestions?  Please leave your comments below.

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Like this? Read more:

Shocking Must-See Video on Vitamin B12 Deficiency Crisis

25 Medications that Cause Vitamin B12 Deficiency

Vitamin B12 Deficiency Disease- Scientists find New Cause

Image courtesy of dream designs/freedigitalphotos

Vitamin B12 and Alzheimer’s Disease

Tuesday, December 8th, 2009

There is some evidence that supports the claim that a vitamin b12 deficiency may actually be the cause of some types of Alzheimer’s disease.

Vitamin B12

Vitamin b12 and Alzheimer’s disease may be linked because as we age the body’s natural ability to absorb certain nutrients changes. Vitamin b12 is one of those vitamins that is absorbed differently as we age. One of the many functions of vitamin b12 is to provide maintenance to nerve cells. Vitamin b12 keeps the nervous system functioning as it should, sending signals back and forth to and from the brain. This action is extremely important to the thinking process. When there is a vitamin b12 deficiency this can mimic Alzheimer’s disease. Supplementing vitamin b12 can help reduce the risk of Alzheimer’s disease in patients that have a known family history. Vitamin b12 and Alzheimer’s disease are a very hot topic in the medical community because of the link that the two share.


There are tests that can be done to see if there is enough vitamin b12 present in the body. This simple blood test will be able to tell if the vitamin b12 in the body is sufficient enough to meet the needs of brain function and other vital functions. Not only is there a link between vitamin b12 and Alzheimer’s disease but there is a well known link between vitamin b12 and anemia. There is genetic testing available to determine if Alzheimer’s disease is genetically predisposed. If there seems to be a genetic factor available, then a regime of high dose of vitamin b12 can be started immediately.

Types of Vitamin B12 Supplements

Vitamin b12 and Alzheimer’s disease may be linked, so the best way to see some benefits from the research is to begin taking a vitamin b12 supplement. Vitamin b12 and Alzheimer’s disease may be the answer to treating Alzheimer’s disease. Taken a vitamin b12 supplement every day may offset the effects of Alzheimer’s disease. Visiting a health care provider to discuss the recommended daily allowance of vitamin b12 and Alzheimer’s disease is a good place to start. A health care provider can best provide information regarding the link between vitamin b12 and Alzheimer’s disease and the recommended daily allowance when trying to treat or offset Alzheimer’s disease. Vitamin b12 supplements come in many different forms and it may be required for the treatment of Alzheimer’s disease that the vitamin b12 supplement is injected for best results.

Where to Find out More about Vitamin B12 and Alzheimer’s Disease

There is an abundance of information regarding recent research in the link between vitamin b12 and Alzheimer’s disease. A good place to start is the internet. Typing in vitamin b12 and Alzheimer’s disease will bring up a wealth of information. Carefully view each entry with a skeptic eye. Ask a health care professional and they may be able to share some information.

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