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Posts Tagged ‘genetic vitamin B12 deficiency’

Vitamin B12 Deficiency- Can it be Genetic?

Monday, October 28th, 2013

 

 

Vitamin B12 deficiency can occur because of diet, medication, or gastrointestinal surgery, but it can also be hereditary. Genetic pernicious anemia is a cause of vitamin B12 deficiency that sometimes slips right off the radar, yet can produce debilitating symptoms of extreme fatigue, disorientation, muscular pain, and depression.

Vitamin B12 Deficiency- Can it be Genetic?

What causes vitamin B12 deficiency?

Listed are just some of the most common causes of vitamin B12 deficiency. For a more complete list, see vitamin B12 deficiency causes.

Diet

Vitamin B12 occurs naturally in animal-based food sources such as fish, chicken, beef, and dairy products. The foods that have the most vitamin B12 are shellfish and organ meats. So if you follow a vegan or vegetarian diet, then it’s vitally important to supplement with vitamin B12 in order to prevent becoming anemic.

Medications

Certain medications can inhibit your ability to digest vitamin B12 from foods; these include PPIs for acid reflux and heartburn, metformin for diabetes, and certain antidepressants.

25 Medications that Cause Vitamin B12 Deficiency

Surgery

Also, if you’ve ever had bariatric surgery (gastric bypass) or gastrointestinal surgery for Crohn’s disease, then you are required to take lifelong vitamin B12 supplements.

Autoimmune diseases

The more autoimmune disorders you have, the likelier your chances of developing new ailments caused by a weak immune system. Vitamin B12 deficiency from pernicious anemia is one such autoimmune disease that can occur alone or along with other genetic autoimmune dysfunctions.

Genetic pernicious anemia is caused by a lack of intrinsic factor, a digestive enzyme needed to absorb vitamin B12.

Pernicious anemia can occur as an autoimmune disorder, or it can develop as a comorbid condition to other autoimmune diseases, such as systemic lupus, rheumatoid arthritis, or celiac disease.

If you eat a healthy diet of lean meats and seafood, and you don’t fall into any of the above-mentioned categories, then your cause of vitamin B12 deficiency may be genetic.

Is vitamin B12 deficiency serious?

Vitamin B12 is crucial for many important biochemical responses throughout your body. Vitamin B12 aids in red blood cell formation, and also sustains healthy neurological functioning.

Vitamin B12 boosts cellular energy, supports a good metabolism, and helps to regulate levels of homocysteine, a hormone linked with heart attack and stroke.

Untreated, long-term vitamin B12 deficiency-pernicious anemia can result severe irreversible damage to your nervous system, increased risk for heart attack and stroke, cognitive impairments, and sometimes, death.

Getting tested

Off the bat, your family medical history can tell you if you’re prone to vitamin B12 deficiency from genetic pernicious anemia. If anybody in your family suffers from pernicious anemia or any autoimmune disorder, then your chances of developing severe vitamin B12 deficiency are higher than normal.

You can test for vitamin B12 deficiency easily with one blood test, but the results are not always accurate. In diagnosing vitamin B12 deficiency, your doctor should pay attention to the symptoms you’re experiencing and how well you’re responding to vitamin B12 supplementation.

Please tell us…

Do you or your parents have vitamin B12 deficiency? Have you found a genetic link to that or other autoimmune disorders?

Do you have any questions or suggestions?  Please leave your comments below.
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Is Vitamin B12 Deficiency a Genetic Mutation?

Tuesday, September 17th, 2013

 

 

About half the population has a gene mutation making them prone to genetic vitamin B12 deficiency, according to researchers, which would explain the growing epidemic of pernicious anemia from untreated vitamin B12 deficiency. About 40 percent of people between the ages of 26 and 83 have dangerously low levels of vitamin B12, and many don’t even realize it until the debilitating symptoms begin to set in. Here are the facts on genetic vitamin B12 deficiency.

Is Vitamin B12 Deficiency a Genetic Mutation?

The MTHFR gene and B12 Deficiency

Everybody has two MTHFR genes, one from each parent. These genes are necessary for efficiently converting vitamin B12 to a usable form, and in effect also maintaining healthy homocysteine levels.

If you have defective MTHFR genes, then you’re not able to convert cobalamin to usable vitamin B12 as effectively as somebody without the gene defect.

However, nearly 50% of all people have a defected MTHFR gene from one parent, and 10% have mutated MTHFR genes from both parents, making them more likely to suffer genetic vitamin B12 deficiency, and also elevated levels of homocysteine, which has been linked to hardening of the arteries and increased risk for heart attack.

Causes for Vitamin B12 Deficiency

Vitamin B12 absorption is a complicated process, and there are many things that can go wrong. Certain health conditions, medications, invasive surgeries, dietary restrictions, and yes- genetics- can impede your ability to digest vitamin B12 properly from food sources and vitamin supplements.

Common causes of vitamin B12 deficiency include:

  • Vegan and vegetarian dieting
  • Family history for autoimmune disorders, such as lupus and fibromyalgia
  • Family history for pernicious anemia
  • MTHFR gene mutations
  • Gastrointestinal infections or illnesses, such as leaky gut, Crohn’s, celiac, and Small Intestine Bacterial Overgrowth (SIBO)
  • Bariatric surgeries or ilium removal for Crohn’s treatment
  • Medications such as metformin for diabetes and PPIs for GERD
  • Old age
  • Alcoholism

Find out if you have genetic B12 Deficiency

There are several ways of finding out if you have vitamin B12 deficiency, including plasma vitamin B12 level screening, complete blood count (CBC) and homocysteine blood screening for Hyperhomocysteinemia.

As for testing for the MTHFR gene mutation, there are no official guidelines as to who should be tested. So unless you request a test for genetic vitamin B12 deficiency from a doctor who is able to comply, then your best bet is to stay on top of vitamin B12 and homocysteine levels, and supplement daily with vitamin B12, folate and vitamin B6.

Treating vitamin B12 Deficiency

If you’re tested with genetic vitamin B12 deficiency caused by a gene mutation, or any form of vitamin B12 deficiency that doesn’t stem from diet, then it’s absolutely essential to supplement with vitamin B12 in order to prevent vitamin B12 deficiency and other severe malnutrition. Diet alone will not provide you the amount of vitamin B12 needed in order to prevent pernicious anemia.

Please tell us…

Would you consider getting tested for genetic vitamin B12 deficiency? Do one or both parents also have vitamin B12 deficiency or pernicious anemia?

Do you have any questions or suggestions?  Please leave your comments below.

Share with your friends!

If you found this article helpful, then please share with your friends, family, and coworkers by email, twitter, or Facebook.

Like this? Read more:

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