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Posts Tagged ‘homocysteine levels B12’

Is Vitamin B12 Deficiency a Genetic Mutation?

Tuesday, September 17th, 2013

 

 

About half the population has a gene mutation making them prone to genetic vitamin B12 deficiency, according to researchers, which would explain the growing epidemic of pernicious anemia from untreated vitamin B12 deficiency. About 40 percent of people between the ages of 26 and 83 have dangerously low levels of vitamin B12, and many don’t even realize it until the debilitating symptoms begin to set in. Here are the facts on genetic vitamin B12 deficiency.

Is Vitamin B12 Deficiency a Genetic Mutation?

The MTHFR gene and B12 Deficiency

Everybody has two MTHFR genes, one from each parent. These genes are necessary for efficiently converting vitamin B12 to a usable form, and in effect also maintaining healthy homocysteine levels.

If you have defective MTHFR genes, then you’re not able to convert cobalamin to usable vitamin B12 as effectively as somebody without the gene defect.

However, nearly 50% of all people have a defected MTHFR gene from one parent, and 10% have mutated MTHFR genes from both parents, making them more likely to suffer genetic vitamin B12 deficiency, and also elevated levels of homocysteine, which has been linked to hardening of the arteries and increased risk for heart attack.

Causes for Vitamin B12 Deficiency

Vitamin B12 absorption is a complicated process, and there are many things that can go wrong. Certain health conditions, medications, invasive surgeries, dietary restrictions, and yes- genetics- can impede your ability to digest vitamin B12 properly from food sources and vitamin supplements.

Common causes of vitamin B12 deficiency include:

  • Vegan and vegetarian dieting
  • Family history for autoimmune disorders, such as lupus and fibromyalgia
  • Family history for pernicious anemia
  • MTHFR gene mutations
  • Gastrointestinal infections or illnesses, such as leaky gut, Crohn’s, celiac, and Small Intestine Bacterial Overgrowth (SIBO)
  • Bariatric surgeries or ilium removal for Crohn’s treatment
  • Medications such as metformin for diabetes and PPIs for GERD
  • Old age
  • Alcoholism

Find out if you have genetic B12 Deficiency

There are several ways of finding out if you have vitamin B12 deficiency, including plasma vitamin B12 level screening, complete blood count (CBC) and homocysteine blood screening for Hyperhomocysteinemia.

As for testing for the MTHFR gene mutation, there are no official guidelines as to who should be tested. So unless you request a test for genetic vitamin B12 deficiency from a doctor who is able to comply, then your best bet is to stay on top of vitamin B12 and homocysteine levels, and supplement daily with vitamin B12, folate and vitamin B6.

Treating vitamin B12 Deficiency

If you’re tested with genetic vitamin B12 deficiency caused by a gene mutation, or any form of vitamin B12 deficiency that doesn’t stem from diet, then it’s absolutely essential to supplement with vitamin B12 in order to prevent vitamin B12 deficiency and other severe malnutrition. Diet alone will not provide you the amount of vitamin B12 needed in order to prevent pernicious anemia.

Please tell us…

Would you consider getting tested for genetic vitamin B12 deficiency? Do one or both parents also have vitamin B12 deficiency or pernicious anemia?

Do you have any questions or suggestions?  Please leave your comments below.

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Like this? Read more:

Shocking Must-See Video on Vitamin B12 Deficiency Crisis

25 Medications that Cause Vitamin B12 Deficiency

Vitamin B12 Deficiency Disease- Scientists find New Cause

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Worried about Low B12 Lab Results?

Sunday, May 8th, 2011

 

 

Did your recent lab work point to vitamin B12 deficiency? A low vitamin B12 blood test is serious. Symptoms of B12 deficiency can include nerve damage, loss of red blood cells, and mood disorders.

WORRIED ABOUT LOW B12 LAB RESULTS? WWW.B12PATCH.COM

What is vitamin B12?

Vitamin B12 is a water-soluble nutrient which your body extracts from food sources such as lean meats, dairy products, eggs and fish. Vitamin B12 is necessary for producing plenty of red blood cells, maintaining a healthy nervous system, regulating homocysteine levels and monitoring DNA synthesis. A blood test which results in low B12 levels means that some of these vital bodily functions could be malfunctioning.

What causes low B12 levels?

There are many factors which can cause your B12 levels to dip dangerously low; these include:

  • Lack of intrinsic factor, a protein which is necessary for proper digestion of vitamin B12 from natural food sources
  • Long-term use of heartburn or antacid medication
  • Following a vegan diet, which excludes foods which are rich in vitamin B12, such as beef, chicken, milk, cheese, yogurt, eggs and fish.
  • Gastrointestinal conditions, such as Crohn’s disease or gluten intolerance
  • Weight loss surgery, such as gastric bypass surgery.
  • Read Anorexic British Teen Regrets Gastric Bypass Surgery

My lab test results indicate vitamin B12 deficiency. Should I be worried?

Due to the fact that it dissolves in water, your body is not able to hold vitamin B12 in the system for long; vitamin B12 must be constantly replenished through protein-rich foods or vitamin B12 supplements, in order to avoid becoming deficient in B12.

Regular lab blood testing is crucial for catching vitamin B12 deficiency before it has a chance to create any lasting impairment. If left untreated, vitamin B12 deficiency can lead to life-threatening illness and irreversible damage. These include:

  • Increased risk for heart attack, due to elevating levels of homocysteine
  • Dementia
  • Irreparable nerve damage
  • Autoimmune disorder
  • Read AIDS with B12 Deficiency

What are the symptoms of vitamin B12 deficiency?

Some low vitamin B12 symptoms are often misdiagnosed as diabetes, mental illness or thyroid disorder.

Below is a list of common symptoms caused by vitamin B12 deficiency:

  • Chronic fatigue
  • Depression
  • Aggression
  • Short-term memory loss
  • Tingling or numbness in hands and feet
  • Difficulty maintaining balance while walking
  • Altered taste perception
  • Dizziness while sitting upright
  • Read: B12 Deficiency can really Get on your Nerves

Treatment

If you are not able to utilize sufficient stores of vitamin B12 naturally, then you must supplement regularly in order to avoid B12 deficiency.

For chronically low B12 levels, doctors have often administered vitamin B12 injections until symptoms abate.

Sublingual tablets are also often prescribed as a preventative measure, but recent studies indicate that under-the-tongue B12 supplements are not the most effective sources of B12, as they are not wholly digestible.

Also read:

New Study: Diabetes Drug Metformin Causes Vitamin B12 Deficiency

B12: Celebs Say it’s the New C

Sources:

LIVESTRONG

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