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Posts Tagged ‘metformin’

What Causes Pernicious Anemia?

Thursday, October 10th, 2013

 

 

There are many causes of pernicious anemia, including autoimmune conditions, medications, and damage to the intestines. Vitamin B12 deficiency caused by vegan dieting is not considered a cause of pernicious anemia, as it can be reversed by eating foods containing ample amounts of vitamin B12.

What Causes Pernicious Anemia?

Digestive illnesses

Crohn’s disease, celiac, and fibromyalgia can impair your ability to produce intrinsic factor, a digestive enzyme that is needed in order to extract vitamin B12 from food and replenish supplies of vitamin B12 in the blood stream. Pernicious anemia is often comorbid with illnesses that affect the gastrointestinal system. For prevention, check vitamin B12 levels routinely and supplement with non-pill forms of vitamin B12.

Shocking Must-See Video on Vitamin B12 Deficiency Crisis

Genetics

If either of your parents or grandparents suffered from pernicious anemia, then you are also a high risk category for vitamin B12 deficiency. With frequent testing, you can catch the onset of vitamin B12 deficiency before it advances to pernicious anemia.

Pernicious Anemia- What’s your Risk?

Medication-induced vitamin B12 deficiency

Certain medications can eventually impair your ability to absorb vitamin B12, leading to pernicious anemia; these include PPIs used to treat GERD (acid reflux), metformin for diabetes, and various antibiotics, NSAIDs and antidepressants. If you are on long-term medication, check to see if you are a risk factor for megaloblastic anemia and use vitamin B12 supplements.

25 Medications that Cause Vitamin B12 Deficiency

Gastrointestinal surgery

If you have had bariatric surgery (gastric bypass) or surgical treatments for illnesses such as Crohn’s disease, then pernicious anemia may result because of vitamin B12 malabsorption. To prevent vitamin B12 deficiency, supplement with non-oral forms of vitamin B12.

Please tell us…

Do you get enough vitamin B12 to prevent symptoms of pernicious anemia, or would you feel better if your doctor would prescribe more vitamin B12?

Do you have any questions or suggestions?  Please leave your comments below.

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Like this? Read more:

Is Pernicious Anemia Megaloblastic?

Vitamin B12 Deficiency and Bariatric Surgery

What are the Symptoms of Pernicious Anemia- B12 deficiency?

Image courtesy of keepingtime_ca/flickr

Pain and Numbness from Vitamin B12 Deficiency

Monday, October 7th, 2013

 

 

If you suffer from pins and needles and painful burning or tingling in your hands and feet, then you may have vitamin B12 deficiency. There are many causes of chronic pain and numbness, most of them strongly linked to extremely low vitamin B12 levels or resulting  pernicious anemia.

Pain and Numbness from Vitamin B12 Deficiency

Getting enough vitamin B12?

Vitamin B12 is an essential nutrient for your nervous system, but sometimes we don’t get enough, either because of diet or underlying health issues.

Eating a vegan diet devoid of B12-rich meats, fish, and cheese is one way of developing vitamin B12 deficiency, but it is also common in the elderly and people who have had gastrointestinal surgery such as gastric bypass.

Vitamin B12 deficiency can also occur with migraine, fibromyalgia, and other forms of chronic pain, as autoimmune history and gastrointestinal problems combine to further raise your chances for developing vitamin B12 deficiency and resulting nerve pain.

If you’re experiencing constant nerve pain and numbness, then you should consider vitamin B12 deficiency as a possible cause.

Vitamin B12 deficiency neuropathy

Neuropathy is any kind of nerve damage that causes intense pain and numbness. Diabetic neuropathy is one of the most common forms of nerve pain, but it can also occur as a result of vitamin B12 deficiency or, if prolonged, pernicious anemia.

Symptoms of vitamin B12 deficiency neuropathy include:

  • Painful numbness and tingling in the extremities
  • Burning or itchy skin rashes
  • Sore burning tongue
  • Difficulty controlling arm and leg movements
  • Muscle spasms

Vitamin B12 and your nerves

Vitamin B12 protects your nervous system by sustaining myelin, a fatty substance that insulates your nerve fibers and enhances intercellular communication, so that sensory messages travel along the spinal cord to the brain quickly and efficiently.

When vitamin B12 levels become depleted, you suffer symptoms resulting from demyelination, destruction of the nerve cell’s outer coating. This is the same process that occurs in patients of multiple sclerosis (MS).

Nervous impulses become slower, and symptoms of tingling, burning, pain and numbness from vitamin B12 deficiency become more frequent.

Untreated, vitamin B12 deficiency can impair your nervous system and cause severe handicaps.

Complex Regional Pain Syndrome (CRPS)

Diabetes

Vitamin B12 deficiency is often comorbid with diabetes. Diabetics taking metformin are at a high risk for developing vitamin B12 deficiency, as metformin is one of several drugs that prevent absorption of vitamin B12 from foods.

If you are a diabetic using metformin, then it’s crucial sustain vitamin B12 levels through supplementation.

Vitamin B12 Deficiency and Fibromyalgia Pain Types

Vitamin B12 deficiency is harder to diagnose in people with diabetes, as the symptoms of pain and numbness are already masked by preexisting diabetic neuropathy. Routine vitamin B12 blood tests are recommended for all diabetics using metformin.

Treating nerve pain and numbness

If nerve pain results from vitamin B12 deficiency, then it’s important to boost your intake of vitamin B12 immediately.

The best, most digestible sources of vitamin B12 are non-dietary supplements that are absorbed into your bloodstream, as opposed to vitamin B12 pills that you swallow.

For best results, start out with 1,000mcg of vitamin B12 weekly or more often, as needed or recommended by your doctor.

Your doctor may prescribe antidepressants for neuropathic pain, or he may advise anti-convulsant drugs. All of these, over extended periods of time, may result in uncomfortable side effects, so use with caution.

Topical treatments used to relive arthritis may help to relieve nerve pain, without any harmful side effects.

Your turn!

If you suffer nerve pain and numbness, have you been tested for vitamin B12 deficiency?

Do you have any questions or suggestions?  Please leave your comments below.

Share with your friends!

If you found this article helpful, then please share with your friends, family, and coworkers by email, twitter, or Facebook.

Like this? Read more:

Do-It-Yourself Chronic Pain Management- 6 Helpful Tips

Help- My Legs keep Falling Asleep!

What are the Symptoms of Pernicious Anemia- B12 deficiency?

Image courtesy of marin/freedigitalphotos

Diabetics, Take Heed

Thursday, December 23rd, 2010

A new study released by the British Medical Journal (BMJ) warns diabetics who take metformin to get their blood checked regularly for vitamin deficiencies, particularly B12.

Sold under the brand name of Glucophage, metformin is often prescribed to patients who suffer from type 2 diabetes.  Metformin increases the body’s receptiveness to insulin while, at the same time, significantly decreasing the amount of glucose secreted by the liver; additionally, it also aids in lowering bad cholesterol.   Scientists, however, have reason to believe that metformin may prevent the body from efficiently absorbing B12, a vitamin which is essential for maintaining a healthy nervous system and red blood cell production.  According to recent research, patients who take metformin are 10% – 30% more likely to have difficulty utilizing B12.  Health experts urge anybody taking the medication over a long period of time to have their B12 levels tested routinely.

B12 deficiency is often misdiagnosed, as its symptoms are similar to those of many other illnesses.

Symptoms include, but are not limited to:

  • Heart palpitations
  • Trouble sleeping
  • Depression
  • Loss of memory
  • Tingling and numbness in the extremities
  • Fatigue
  • Nervousness
  • Slow reflexes
  • Slow blood clotting
  • Dandruff
  • Trouble swallowing
  • Red or sore tongue
  • Menstrual complications

Treatment for B12 deficiency may include a series of B12 vitamin supplements taken in the form of intramuscular injections.

References:

Bloomberg Businessweek

Web MD

Diabetes Self-Management

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