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Posts Tagged ‘Vitamin B-12 Injection’

Vitamin B12 Injection

Sunday, January 14th, 2007

An Overview Of Intravenous Vitamin B12

Vitamin B-12 is necessary for many things, including growth, cell reproduction, and hematopoiesis. Generally vitamin B12 is administered in the form cyanocobalamin, which is absorbed in the muscles at the site of the injection. The level of plasma in the compound is found to be at its peak within an hour after the intramuscular injection is given. Almost 1000 micrograms, that is 50- 98 percent of vitamin B12, is present in the urine within 48 hours of the injection. Most of vitamin B12 is excreted in the urine. Some vitamin B12 is also absorbed through the intestinal tract.

Vitamin B-12 Injection

Vitamin B12 injection is in the form of Cyanocobalamin in a clear red, sterile and nonpyrogenic aqueous solution. The dosage for intramuscular injections is 1000 micrograms per milliliter.  The solution is hygroscopic in anhydrous form and also soluble in water.  The coenzymes of vitamin B12 in the solution are very unstable in the presence of light.  Apart from vitamin B12, the active ingredients of Cyanocobalamin injections are benzyl alcohol (as a preservative) and sodium chloride (for isotonicity).  It is important to know that doses of vitamin B12 that exceed 10 micrograms daily are capable of producing a hematologic response in patients who have folate deficiency. Also, pareteral administration of vitamin B12 can sometimes cause anaphylactic shock and even death.

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