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Signs and Symptoms of 6 Types of Anemia Blood Disease



Pernicious Anemia, Sickle Cell, and Others: Anemia is a serious blood disease resulting in low blood cell production; aside from vitamin B12 deficiency from pernicious anemia, how many other types of anemia are there?


What are the different kinds of anemia?

There are six general types of anemia.  They include:

Pernicious Anemia (PA)

Pernicious anemia is an acquired disease that causes vitamin B12 deficiency.  Vitamin B12 is crucial for producing healthy red blood cells, in addition to supporting your nervous system, promoting mental clarity, and optimizing your metabolism. With pernicious anemia, you are unable to absorb vitamin B12 from natural food sources, resulting in severe depletion of vitamin B12 levels in your blood.

Symptoms of vitamin B12 deficiency include:

  • fatigue
  • dizziness
  • tingling in your hands and/or feet
  • “brain fog”
  • memory loss
  • depression
  • aggression.

If diagnosed with pernicious anemia, your doctor may recommend weekly vitamin B12 injections, which are inserted in the thick thigh muscle or buttock.  Vitamin B12 shots require a prescription, may cause bruising, and are usually painful.

As an alternative, patients may opt for gentle over-the-counter (OTC) vitamin B12 supplements that don’t  require injection.

Also read: B12 Deficiency can really Get on your Nerves

Hemolytic Anemia (HA)

Hemolytic anemia occurs when red blood cells are destroyed (hemolysis) at a rate that is quicker than their reproduction in bone marrow.  People who have hemolytic anemia have either inherited it as a genetic disease, or acquired it later in life.  Mild hemolytic anemia does not usually require treatment, but severe anemia can be life-threatening, requiring blood transfusions, steroids, or splenectomy.

Sickle Cell Anemia (SCA)

Sickle cell anemia is an inherited blood disease.  In sickle cell anemia, abnormally shaped hemoglobin cells become obstructed in small blood vessels, causing pain and possible organ damage to the anemic individual.  There is no cure for sickle cell anemia, but therapies for reducing the symptoms of anemia include antibiotics, pain relievers, and blood transfusions.


Aplastic Anemia (AA)

Aplastic anemia is a blood disease that can be life threatening.  In aplastic anemia, your bone marrow is unable to produce sufficient amounts of crucial blood cells, including red blood cells, white blood cells, and blood platelets.  Diagnosis of anemia includes testing that indicates low blood count of any of the three blood cells types.  Causes of aplastic anemia include autoimmune disease (most common) or exposure to chemotherapy and other types of radiation.  Possible treatments for aplastic anemia include bone marrow transplants, blood transfusions, and restraining of the immune system.  Untreated, aplastic anemia can be fatal.

Fanconi Anemia (FA)

Fanconi anemia is a rare blood disorder, and it is inherited as a genetic disease. Fanconi anemia involves bone marrow failure, and can lead to myelogenous leukemia. Even with bone marrow transplants, patients of Fanconi anemia rarely live past the age of thirty.

Bone Marrow Disease Anemia

Sometimes, bone marrow diseases, such as leukemia and myelodysplasia (pre-leukemia), create symptoms of anemia in patients, as diseased bone marrow causes inadequate production of red blood cells.

Related reading:

“I’ve heard of the X Factor and Fear Factor…But what’s Intrinsic Factor?”

B12 Deficiency: Don’t Ignore the Symptoms

AIDS with B12 Deficiency


Anemia: Types of Anemia- Healthplus24.com

What Are the Signs and Symptoms of Pernicious Anemia? -NHLBI, NIH

Images courtesy of FreeDigitalPhotos.net

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2 Responses to “Signs and Symptoms of 6 Types of Anemia Blood Disease”

  1. Janice Yearta Says:

    I was diagnosis with B-12 deficiency back in 2007, this is due to beening on anti-seizure medication for a long period of time.
    Since 2007 I 1st. started out with the tablets, then the shots. It took a long time to get my B-12 level up.

    I have a bad reaction to the shot and to the B-complex liquid (w/o folic acid) My heart races, I become agitated, extreme irritabel, irrational.
    I have told all my Dr. , on one has heard of this reaction.

    I am have deficiency of folic acid, and I can not take over the counter folic acid. This causes seizures.

    It has been for years since I was diagnosed, I would not take the B-12, except for the fact, I get so fatigue I can’t get out of bed. My memory becomes inpaired, numbness in my feet.

    If anyone reads this and is able to help me, I would appreciate it so very much.

  2. linda Says:

    Hi Janice-

    I’m not surprised that the B12 tablets didn’t work- the sublingual B12 pills are not the most digestible form at all, though doctors continue to prescribe them.

    Depression is one of the signs of B12 deficiency, in addition to memory loss, numbness and fatigue, and it sounds like you have all of those symptoms, if not more. This is important- the symptoms will not go away unless you take some form of vitamin B12. Untreated, the results could be devastating (anemia, neurological damage).

    I highly recommend giving the B12 patch a try. We have heard from many satisfied “patchers” who have claimed that switching to the B12 patch has turned their life around- people who are not able to digest vitamin B12 naturally (which might be your situation), and have responded badly to B12 injections.

    Please keep us updated, and thank you for your interest in the B12 patch.

    Be well.


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